99% Purity Bodybuilding Sarms Powder Aicar Acadesine CAS 2627-69-2

Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

Function:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits in-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.


Biological Activity:
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers in-independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin 

Our advantage

Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.

Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
We have special way could ship 0.01kg to 2kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

Good after-sales service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.

Our Service:
Payment method: Paypal, Western Union, Moneygram, TT.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3 days after payment

WHY CHOOSE US?
1, high quality with competitive price

1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery

1)Parcel can be sent out in 1 day after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
4) Customs pass rate ≥ 99%!

3, We have clients throughout the world

1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Any inquiries will be highly appreciated, meeting customer's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
4)Best after-sales service!

 

 

99% Purity Bodybuilding Sarms Powder Aicar Acadesine CAS 2627-69-2

Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

Function:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits in-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.


Biological Activity:
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers in-independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin 

Our advantage

Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.

Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
We have special way could ship 0.01kg to 2kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

Good after-sales service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.

Our Service:
Payment method: Paypal, Western Union, Moneygram, TT.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3 days after payment

WHY CHOOSE US?
1, high quality with competitive price

1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery

1)Parcel can be sent out in 1 day after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
4) Customs pass rate ≥ 99%!

3, We have clients throughout the world

1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Any inquiries will be highly appreciated, meeting customer's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
4)Best after-sales service!