Pharmaceutical Raw Material Rosiglitazone CAS 122320-73-4

Rosiglitazone
Synonyms:5-(4-[2-(Methyl-Pyridin-2-Yl-Amino)-Ethoxy]-Benzyl)-Thiazolidine-2,4-Dione;5-[[4-[2-(Methyl-2-Pyridinylamino)Ethoxy]-Phenyl]Methyl]-2,4-Thiazolidine-Dione;Avandia;Rosiglitazone HCL;Rosiglitazone free base
CAS:122320-73-4
MF:C18H19N3O3S
MW:357.43
Melting point:153-155ºC
Uses:A potent and selective PPARγ agonist.

Pharmacology


Rosiglitazone is a member of the thiazolidinedione class of drugs. Thiazolidinediones act as insulin sensitizers. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). PPARs are transcription factors that reside in the nucleus and become activated by ligands such as thiazolidinediones. Thiazolidinediones enter the cell, bind to the nuclear receptors, and alter the expression of genes. The several PPARs include PPARα, PPARβ/δ, and PPARγ. Thiazolidinediones bind to PPARγ.

PPARs are expressed in fat cells, cells of the liver, muscle, heart, and inner wall (endothelium) and smooth muscle of blood vessels. PPARγ is expressed mainly in fat tissue, where it regulates genes involved in fat cell (adipocyte) differentiation, fatty acid uptake and storage, and glucose uptake. It is also found in pancreatic beta cells, vascular endothelium, and macrophages. Rosiglitazone is a selective ligand of PPARγ and has no PPARα-binding action. Other drugs bind to PPARα.


Rosiglitazone also appears to have an anti-inflammatory effect in addition to its effect on insulin resistance. Nuclear factor kappa-B (NF-κB), a signaling molecule, stimulates the inflammatory pathways. NF-κB inhibitor (IκB) downregulates the inflammatory pathways. When patients take rosiglitazone, NF-κB levels fall and IκB levels increase.
 

Other Small molecular API:

 

 
How to proceed your order:
Step 1: Please let me know the items you are favorable, quantities, and the destination country.
Step 2: You confirm all detail, and offer purchasing order.
Step 3: We send the detail price of our product and offer the suitable shipping method for reference.
Step 4: You confirm the order and pay mony 100% in advance and send us the detailed contacting information, including contacting person/company, address, mobile number, ZIP code and your special requirements.
Step 5: We arrange the shipment according to your requirements, and tracking code will be offered after claiming the payment within 24h, then you can track your parcel at any moment.
Step 6: We offer after-sales services after service after you receive your parcel.
 
 
OUR ADWANTAGE:
 
1,High quality with competitive price:
1)Standard: Enterprise Standard 
2)All Purity≥99%
3)We are manufacturer and can provide high quality products with factory price.
 2,Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥99%
4)  We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
 3,We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers

Rosiglitazone
Synonyms:5-(4-[2-(Methyl-Pyridin-2-Yl-Amino)-Ethoxy]-Benzyl)-Thiazolidine-2,4-Dione;5-[[4-[2-(Methyl-2-Pyridinylamino)Ethoxy]-Phenyl]Methyl]-2,4-Thiazolidine-Dione;Avandia;Rosiglitazone HCL;Rosiglitazone free base
CAS:122320-73-4
MF:C18H19N3O3S
MW:357.43
Melting point:153-155ºC
Uses:A potent and selective PPARγ agonist.

Pharmacology


Rosiglitazone is a member of the thiazolidinedione class of drugs. Thiazolidinediones act as insulin sensitizers. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). PPARs are transcription factors that reside in the nucleus and become activated by ligands such as thiazolidinediones. Thiazolidinediones enter the cell, bind to the nuclear receptors, and alter the expression of genes. The several PPARs include PPARα, PPARβ/δ, and PPARγ. Thiazolidinediones bind to PPARγ.

PPARs are expressed in fat cells, cells of the liver, muscle, heart, and inner wall (endothelium) and smooth muscle of blood vessels. PPARγ is expressed mainly in fat tissue, where it regulates genes involved in fat cell (adipocyte) differentiation, fatty acid uptake and storage, and glucose uptake. It is also found in pancreatic beta cells, vascular endothelium, and macrophages. Rosiglitazone is a selective ligand of PPARγ and has no PPARα-binding action. Other drugs bind to PPARα.


Rosiglitazone also appears to have an anti-inflammatory effect in addition to its effect on insulin resistance. Nuclear factor kappa-B (NF-κB), a signaling molecule, stimulates the inflammatory pathways. NF-κB inhibitor (IκB) downregulates the inflammatory pathways. When patients take rosiglitazone, NF-κB levels fall and IκB levels increase.
 

Other Small molecular API:

 

 
How to proceed your order:
Step 1: Please let me know the items you are favorable, quantities, and the destination country.
Step 2: You confirm all detail, and offer purchasing order.
Step 3: We send the detail price of our product and offer the suitable shipping method for reference.
Step 4: You confirm the order and pay mony 100% in advance and send us the detailed contacting information, including contacting person/company, address, mobile number, ZIP code and your special requirements.
Step 5: We arrange the shipment according to your requirements, and tracking code will be offered after claiming the payment within 24h, then you can track your parcel at any moment.
Step 6: We offer after-sales services after service after you receive your parcel.
 
 
OUR ADWANTAGE:
 
1,High quality with competitive price:
1)Standard: Enterprise Standard 
2)All Purity≥99%
3)We are manufacturer and can provide high quality products with factory price.
 2,Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥99%
4)  We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
 3,We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers