The "Black Technology" Behind the Bottom of Rapid Stopping Blood Magic Glue——A New Breakthrough of Chinese Scientists' Photocrosslinking Biomaterials

Professor Zhu Linyong from East China University of Science and Technology teamed up with Professor Ouyang Hongwei from Zhejiang University School of Medicine to develop a biomimetic hydrogel material that can completely stop aortic injury and cardiac penetrating hemorrhage within seconds. Related research papers recently published in "Nature Communications" on the topic "A superabsorbent hydrogel material for hemostasis repair of arteries and heart damage".

It is reported that once the results have been reported, it has attracted widespread attention from the British Daily Mail, NewScientist, BioArt, DeepTech and other media, and called it "miracle glue" (A "miracle" glue), there are also many media called rapid hemostasis. "Black technology" and so on.

The success of the development of this hydrogel material called "Hydrogel" is no accident, behind the numerous research and efforts of countless researchers. What kind of "black technology" is hidden behind "magic glue"? The research progress of the research group of Professor Zhu Linyong of East China University of Science and Technology in recent years in the field of photocrosslinking biomaterials may be the best explanation.

Since entering the research group of East China University of Science and Technology in 2007, Zhu Linyong has always led the team to focus on the research of “photochemical methods for constructing biomedical materials” and has formed characteristics.

As early as ten years ago, Zhu Linyong noticed that the photo-crosslinking biomaterials have achieved subversive success in dental repair, especially for clinical operation, almost completely replacing the traditional amalgam materials. He realized that if this technology is expanded To the soft tissue application level, the “easy-to-use” characteristics of photocrosslinking are bound to provide innovative means for solving many clinical practical problems such as wound closure, hemostasis and repair.

In fact, the biomaterials community has formed a consensus that the biomimetic hydrogel material with the most similar biological soft tissue is a tool for soft tissue repair. However, the free radical-mediated photocrosslinking curing mechanism that has been used in the past has always been free of the inherent drawbacks of free radicals, such as biotoxicity, oxygen inhibition, and thin layer gelation; the resulting hydrogel or " Soft and weak or "hard and brittle", lacking toughness and inability to adhere to moist, dynamic tissue surfaces. This status quo has led to a large number of articles published in the field of photocrosslinked hydrogel biomaterials, but the actual clinical transformation and application is severely limited.

In response to the above problems, Zhu Linyong led the team's young teachers Lin Qiu-Ning and Professor Bao Chunyan to open the difficult road of optical cross-linking hydrogel biomaterials innovation construction and clinical transformation in 2012, and achieved a series of scientific research results: 2014, Zhu Linyong The research team has taken a different approach and proposed the non-free radical crosslinking mechanism of “photocoupled reaction” in the world. It has achieved low toxicity and controllable construction of hydrogels, effectively overcoming the defects of free radical toxicity of traditional photocrosslinking mechanisms. The industry is praised as “a new breakthrough in photocrosslinking hydrogel technology”; in 2015, multi-step controllable “photo-coupling reaction” cross-linking was realized; in 2017, based on “photo-coupling reaction”, cells were realized. Manipulation of adhesion, proliferation and migration in hydrogel scaffolds; in 2018, further expanded 3D fast photocrosslinking of "photocoupled reactions" in multi-wavelength, large-scale and deep-thickness hydrogel materials Molding applications. The above "photocoupled reaction" cross-linking has broken through many barriers of the traditional free radical mechanism, and successfully achieved the effective combination of controllable and low toxicity of photocrosslinking hydrogel.

In order to further break through the traditional challenge of "weak" and "smooth" hydrogels that cannot adhere to the wet, dynamic tissue surface, Zhu Linyong's team proposed the development of a "photocoupled reaction" capable of covalently bonding to the surface of the tissue. A photo-in situ gel technique with tissue adhesion and integration properties was established. Once published, Global Medical Discovery was reported as a “Key Scientific Article” (important scientific paper).

Based on these technological advantages, the Zhu Linyong team further cooperated with relevant medical units in 2014 to verify the effectiveness of the above optical in situ gel technology on animal models. It has been verified that the hydrogel material has the following functions: First, it can be used as a wound hemostatic sealing material. Its high strength, strong tissue adhesion and rapid solidification can achieve large-flow bleeding caused by penetrating injury of large animals. Transient closure of arterial injury; second, it can be used as an in situ gel scaffold for stem cells or their exosomes. Its tissue adhesion properties contribute to the repair of cartilage defects and promote the integration of new cartilage and old cartilage; It can be used as a prosthetic repair material to promote the "photo-coupling reaction" cross-linking of autologous platelet-rich plasma (PRP) without any modification, and form a high tissue adhesion promoting wound repair gel in situ. .

Based on the above “photocoupled reaction” in-situ gel technology with biosafety, ease of use and unique tissue adhesion and integration advantages, Zhu Linyong research team completed the intellectual property rights of raw materials, preparation, products and applications of the above technologies. On the basis of comprehensive layout, the company further cooperated with relevant medical units and enterprises to implement clinical transformation of “medical photosensitive bio-adhesive” products based on the original technology, and completed the pilot production, storage stability and effectiveness of animal models. And third-party security certification (CFDA certification body).

"It is expected that the 'medical photosensitive bio-adhesive' product will pass the CFDA innovative medical device channel in the near future, and finally approved three types of medical device registration certificates, which substantially break through the current 'fibrinogen' and 'cyanoacrylate' medical glue. The surface of the wet tissue has no application bottlenecks such as bonding and biotoxicity," said Professor Zhu Linyong.

It is reported that around the "photocoupled reaction" in-situ gel technology, Professor Zhu Linyong's research group has applied for 6 domestic invention patents and 3 international PCT patents; 1 Chinese invention patent authorization and 1 US invention patent authorization. Submitted 2 US patents, 1 European patent, and 1 Japanese patent.

Related paper information: https://doi.org/10.1038/s41467-019-10004-7

Source: Science Network

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